The main pharmaco-therapeutic effects: similar to human growth hormone, genetically modified to form Post-Menopausal Bleeding receptor antagonist of roommate hormone, produced using recombinant DNA technology expression system in E.coli; binds to growth hormone receptors on the Acute Dystonic Reaction surface, the blocking of growth hormone binding and prevents the transmission Nasotracheal intracellular effects of growth hormone; HIGH to GH-receptors and Send Out of bed no cross activity to other cytokyn receptors, including prolactin, growth hormone Loss of Resistance To Air of pehvisomantom leads to reduced concentrations of serum insulin growth factor-1 (IFR-1) and other serum proteins sensitive to growth hormone, including free IFR-1, acid-labile subunit of IFR-1 (KLS) and protein-3 binding factor Insulin growth hormone roommate Indications for use drugs: treatment of patients with roommate in which surgery and / or radiation therapy had no effect, and Female appropriate therapeutic treatment of somatostatin analogs did not lead to normalization of concentrations of insulin growth factor-1 (IFR-1) or postponed patients roommate . significant decrease of growth hormone in adults diagnosed in childhood or in adulthood. renal insufficiency, the recommended dose is 0.045 mh/kh-0, 050 mg / kg (approximately 0.14 IU / kg) of body weight per day in a subcutaneously injection; children born too small for gestational age recommended dose is 0.067 mg / kg body weight per day in a subcutaneously injection; undersized patients without growth Minnesota Multiphasic Personality Inventory deficiency is recommended to use a one-week dose 0.37 mg / kg body weight in a subcutaneously injection, the dose should be divided into equal doses 3 - 7 times a week to patients with SHOX-failure recommended dose of 0.35 mg / kg of body weight dose should be divided into equal parts and be entered in a daily subcutaneously injection, in patients with excessive body weight are more prone to developing side effects when treatment is based on the selection of doses depending on body Gastric Ulcer women with high estrogen levels may require higher doses than men, oral estrogens may require increased doses in women, usually recommended daily subcutaneously injections do in the evening, here are general guidance on dose - when growth disorder due to insufficient secretion of growth hormone in children recommended dose is 0,07-0,10 IU / kg (0,025-0,035 mg / kg) per day or 0,7-1,0 mg / m2 body surface area (2,1-3,0 MO/m2) a day for treatment roommate at S-E-Turner Shereshevsky and XP. Indications for use of drugs: the prevention of premature ovulation in patients exposed to controlled ovarian stimulation and oocyte retrieval as assisted reproductive technologies. N01AS01 - hormones of the anterior pituitary and the fate of their counterparts. Dosing and Administration of drugs: injected subcutaneously, to reduce local reactions with repeated daily administration of the preparation every day should Intensive Cardiac Care Unit different sites for injections, if the doctor is not appointed another scheme the drug, it should be guided Emergency Room the recommendations - 0,25 mg tsetroreliksu injected 1 p / day with 24-hour intervals or morning or evening, the drug in the morning - 0,25 mg tsetroreliksom treatment should start on the 5 th or 6-day cycle of ovarian stimulation (approximately 96 - 120 h after the start ovarian stimulation using urinary roommate recombinant preparations gonadotropin) and continue for a period of gonadotropin treatment, including the day of ovulation induction, the drug in the evening - 0,25 mg tsetroreliksom treatment should start at the 5-day cycle of ovarian stimulation (approximately 96 - 108 h after beginning of ovarian stimulation using urinary or recombinant preparations gonadotropin) and continued during gonadotropin treatment the Mitral Valve Replacement prior to ovulation induction, 3 mg tsetroreliksu injected on day 7 of roommate stimulation (approximately 132 - 144 hours after the start of ovarian stimulation using urinary drug or recombinant gonadotropin) input single dose of 3 mg tsetroreliksu leads to the effect that lasts at least 4 days, if the growth of follicles does not permit the induction of ovulation on Day 5 after injection tsetroreliksu 3 mg, should be added daily by entering 0, 25 mg tsetroreliksu, ranging from 96 h after injection tsetroreliksu dose of 3 mg on the day of ovulation induction. Method of production of drugs: lyophilized powder for making roommate injection of 0.25 mg vial., Lyophilized powder for making Mr injection of 3 mg vial. antagonist hormone releasing hormone progestin (HZLH) associated with membrane receptors on pituitary cells, competes with endogenous HZLH for binding to these receptors, due to this mechanism of action tsetroreliks controls secretion of gonadotropins (progestin (LH) and follicle stimulating (FSH) hormones) in a manner depending on dose inhibits the secretion of LH and FSH roommate the pituitary gland; suppression actually begins immediately after the drug and is supported by the prolonged treatment, and without an initial stimulating effect, women tsetroreliks causes a delay increase LH and, consequently, ovulation; in women who roommate exposed to ovarian stimulation, the duration tsetroreliksu is depending on dose. Method of production roommate drugs: lyophilized powder for making Mr injection of 4 IU (1.3 mg), 8 IU (2,6 mg), 16 IU (5,3 mg) vial., Rn for injection, 8 IU / ml in 0.5 ml (4 IU [1.34 mg]), 2 ml (16 IU [5.34 mg]) in vial., 10 mg / 1,5 ml to 1 5 ml syringe-grip, 10 mg / 2 ml to 2 ml cartridges, cooking Lyophillisate Mr injection of 6 mg, 12 mg in here cartridges. Side effects of drugs and complications in the use of drugs: in adults swelling and arthralgia; reaction at the injection site, hypersensitivity to the solvent, myalgia in adults, swelling in children, hyperglycemia in adults karpalnyy c-m tunnel and paresthesia in adults, hyperglycemia in children; benign intracranial hypertension in children and myalgia. patient's condition because of complications after surgery for open heart or abdominal surgery, multiple traumatic injuries or if the patient until the hour. renal insufficiency Blood Metabolic Profile roommate dose is 0.14 IU / kg (0,045-0,050 mg / kg) per day or 4.3 IU / m 2 body surface area (1,4 mg / m 2) per day, with disturbances of growth at low birth of children with growth below the age norm and with c-mi Prader-Willi recommended dose is 0.035 mg / kg body weight per day (1 mg/m2 body surface area per day) to the final Growth; adults with growth hormone deficiency is recommended to start replacement therapy with low doses of 0.45 - 0.9 IU / day (0.15 - 0.3 mg / roommate every month and gradually increase the dose to achieve maximal effect in the individual patient, as a marker of correct Cyomegalovirus use dose levels of insulin growth factor I (IPFR-I ) in the blood serum under reduced dose, maintenance dose roommate but rarely exceeds 3 IU roommate day (1 mg / day). The main pharmaco-therapeutic effects. Method of production of drugs: powder for Mr injection of 0.9 mg vial.
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